no slot position? so does that mean 1 qb, 2 wr, 2 rb, 1 te, 1 k for offense?
i think best is a great 3rd option. if he misses time, i think that makes ronnie brown a good option as his fill in. this is a tough call... i'd say delmarco murray is the better short term plug in b/c he's more likely to get time. but what if jahvid best misses extended time (however unlikely)? then ronnie brown is the clear better pickup since murray will likely only get a few weeks of run. and if best doesn't miss any time, then you should start best over murray. if what i just said made any sense, to sum it up i'm thinking maybe go with the det RB situation altogether... i'm sorry, i'm too tired to put these rambling thoughts together coherently.
p.s. that's incredible that you have brady, chris johnson, and greg jennings in a 16 team league...