Biggest problem I see with the Lakers is shooting.
Worthy, Rondo, Payton, Garnett are all less than average (for their position) 3pt shooters, so I guess the biggest worry I have with the lakers is that they're going to have a smaller court, as it were.
Dumars and Majerle are both more than able shooters, but Domars is the only one seeing real time.
On a real NBA team, this wouldn't be an issue. A real NBA team though wouldn't have to contend with dominating players at every position on the other side tough. Lets say Big Game James is matching up against a Shawn Marion. Marion can sag off him when Worthy doesn't have the ball, because he's good enough, long enough, and fast enough to get back on Worthy if he is going to shoot it, and Worthy is only a 30% shooter, and if Worthy's not going to shoot it, Marion can still defend him without allowing him into the paint.
Meanwhile, while Marion is playing off the ball, he's taking him passing lanes and space that Payton and Rondo need to get their guys the ball, and driving lanes they'd need to use to get to the basket.
Its a crappy place to focus on a team that is so talented athletically and physically, but I don't think it should be overlooked, as every weakness that cannot be addressed is going to be a focal point in a league where none of the teams should have any chinks in their armor.