Nene is a tough matchup for Perk.
Too mobile, too many PnRs, transition opportunities, cuts, midrange jump shots and the odd face up and drive. Perk will do well in low post situations but all those other types of baskets are firmly to Nene's advantage.
Serge Ibaka's help defense is going to be the key to keeping Nene in check. Not Perk.
Although, Perk can still have a big impact with his team defense + rebounding.