Eddie Murphy is the one and only, just because he went out on top it doesn't mean that he's still not of that status, he's MJ and crappy kids movies are his Wizards and Bobcats.
After him Mitch was pretty good, I'm a huge fan of Norm MacDonald and Tracy Morgan but those are an acquired taste, especially Morgan, it seems to me that very few people see through the shock humor to his true genius. Russell Peters and Jason John Whitehead are good for Canadian humor fans. Russell Peters dominates Canada right now actually. Seinfeld's a genius, the thing I love about him is he never wastes a word, he's so good at it it's hard to even watch sometimes.