The Spurs are a perfect storm so far this season. If the Spurs stay healthy, I'd rather play the Lakers. If Bryant has a bad game, the Lakers are very beatable.
More than half of the Spurs roster has led the team in scoring at least once this season. Starters minutes are in the low 30s or less. They still have by far the best record in the NBA. Barring injury this is going to be a very fresh team come playoff time.