Gosh. This is a really tough question.
Oden: Here's the thing: the guy can play...um...could possibly play if he ever is healthy. The thing is, like a certain Bill Walton in Portland before him, if he gets one healthy season, the team is a contender that year (provided they're okay at the other spots). If he's consistently available for limited minutes, he's Bill Walton circa 1986 championship (presumably behind Camby at the moment). He's worthless in trade. The touch question will be a QO at $9 million. He'll need an incentive-laden contract for the rest of his career to protect whatever franchise gambles on him.
Roy: Again, worthless in trade. They're stuck with him.
Aldridge is a keeper, plain and simple, but isn't enough by himself. Still, why get rid of a piece when the problem is finding another?
The way I read that roster, Camby, Przbilla, and A.Miller are the only other guys making any serious dough, with Przbilla expiring this year, and the other two in 2012.
So, they're not in bad shape in terms of salary, but should perhaps try to flip any of these guys for a scorer (i.e. Iguodala) that could complement Aldridge (in Roy's absence), and work like heck on being a top defensive team, while praying that Roy/Oden's health comes together for at least one season+playoffs.
So, in answer to the OP, I don't think blowing it up is really an option, but their good-to-great jump will depend completely on the health of Roy/Oden, and there's nothing they can do about it.