I can't pick against Peyton Manning.
I can't stand the guy and I want to see him get hit 10x more than Brett Favre got hit in the NFC Championship game, but he's just too good. Even though the Saints seem like a more well rounded team and the Colts didn't face any kind of real, tough competition to get to the Superbowl (two teams that barely made the playoffs), I still predict that the Colts will win.
The more I hear about the matchup and the more I think about it, the more I think the Colts are going to dominate this game. I'm kind of hoping that I'm going to jinx the Colts, though; so far in this post-season every time I've been 100% sure a team was going to win, they lost.
So there's that at least.