This is not all telling but you can sort 2-man line up stats.  I sorted by the best total +/- for each team:
1. UTA  Gorbert/Conley       1368 min / +528
2. PHI  Embiid/Simmons     1164 min / +393
3. LAC  George/Leonard      1028 min / +378
4. DEN  Jokic/Murray           1363 min / +339
5. MIL  Giannis/Middleton   1452 min / +322
6. PHO  Booker/Bridges       1870 min / +279
7. GWS  Green/Curry           1738 min / +278
8. POR  Covington/Lillard    1805 min / +257
9.  ATL Collins/Young         1455 min / +239
10. BKN Irving/Harris         1293 min / +196
11. MIA Butler/Robinson     1177 min / +190
12. MEM Valanci'/Brooks      1314 min / +165
13. LAL  James/Schroder      816 min / +162
14. NYK Randle/Bullock       1811 min / +122
                        Barrett
15. NOP Williamson/Ball      1114 min / +112
15. SAS Poeltl/Murray         1307 min / + 106
16. TOR Siakam/VanFleet    1466 mn / +96
17. BOS Tatum/Brown         1263 min / +79
There are a number of top duos that either didn't have the minutes to qualify for my sort or that were on lesser teams that just didn't have the same level of +/- success.  Also, for many of the teams, they had more than one 2-man group that did very well.  For example, Utah had 7 of the top 10 and Gobert was part of 6 of those 7.  Again, I just listed the top one for each team.
I also note that most of these duos include one big.  12 of the top 17.  I did a per 36 sort to normalize against time but that really did not change things all that much.  Utah/Gobert were still most of the best duos.  Harden and Durant are clearly a top duo but this didn't make my sort due to not enough minutes on the floor together.   Lillard/McCullom were 1068 min/+221, not the best on POR for total but best per 36 on POR.
Tatum and Brown did not fare so well in this comparison.