This is not all telling but you can sort 2-man line up stats. I sorted by the best total +/- for each team:
1. UTA Gorbert/Conley 1368 min / +528
2. PHI Embiid/Simmons 1164 min / +393
3. LAC George/Leonard 1028 min / +378
4. DEN Jokic/Murray 1363 min / +339
5. MIL Giannis/Middleton 1452 min / +322
6. PHO Booker/Bridges 1870 min / +279
7. GWS Green/Curry 1738 min / +278
8. POR Covington/Lillard 1805 min / +257
9. ATL Collins/Young 1455 min / +239
10. BKN Irving/Harris 1293 min / +196
11. MIA Butler/Robinson 1177 min / +190
12. MEM Valanci'/Brooks 1314 min / +165
13. LAL James/Schroder 816 min / +162
14. NYK Randle/Bullock 1811 min / +122
Barrett
15. NOP Williamson/Ball 1114 min / +112
15. SAS Poeltl/Murray 1307 min / + 106
16. TOR Siakam/VanFleet 1466 mn / +96
17. BOS Tatum/Brown 1263 min / +79
There are a number of top duos that either didn't have the minutes to qualify for my sort or that were on lesser teams that just didn't have the same level of +/- success. Also, for many of the teams, they had more than one 2-man group that did very well. For example, Utah had 7 of the top 10 and Gobert was part of 6 of those 7. Again, I just listed the top one for each team.
I also note that most of these duos include one big. 12 of the top 17. I did a per 36 sort to normalize against time but that really did not change things all that much. Utah/Gobert were still most of the best duos. Harden and Durant are clearly a top duo but this didn't make my sort due to not enough minutes on the floor together. Lillard/McCullom were 1068 min/+221, not the best on POR for total but best per 36 on POR.
Tatum and Brown did not fare so well in this comparison.