Obviously you're fighting long odds beating the top teams in the league with bench players. But on any given night I think virtually any team could win a single game.
My starting lineup:
Brogdon, Lou-Will, Oubre, Lyles, Sabonis
Reserves:
C. Joseph, J. Harris, J. Lamb, M. Beasley, J. Collins
I would want to have good size and athleticism at every position, if possible. Lou-Will being the exception because he's the only truly elite bench scorer available. I don't think I could get away with trying to use guys like Wade, Hield, or Gay.
While this is obviously a doomed exercise, putting together a team of Generals to go against the Globetrotters, but I think it's an interesting challenge (particularly with an eye toward playing it out in 2k18).