If you're going back to what really kicked off the modern era of ensemble cast dramas, you have to start with Hill Street Blues, St Elsewhere and LA Law. They were groundbreaking and great but don't hold up to the evolved Breaking Bad, Wire or Shield (I don't think Wire was any better than Shield), and GOT. I think Sopranos gets a top 10 nod as should Lost and West Wing-- these shows all kicked their genres up a notch.. I am also partial to Treme, Rectify, Newsroom, Deadwood, and House of Cards
Son of A got old for me after 2 seasons and also included what I considered the worst acting performance in any of the dramas named on this thread (Kate Segal -- repulsive character poorly played). Mad Men was well-written and well acted but did not have a single character that I found likeable (or even one i loved to hate).
Seinfeld, Curb, and Arrested Development top my Cable era comedies. I love Louis and it gets better with each season.
BTW, I know many will disagree but I thought Married with Children was just awful. I put it in the same category as Three's company, Two1/2 Men, Alice --- long-running shows that lived off the same jokes and basic plot lines for years relying almost exclusively on sex humor, toilet humor and ever-repeating catch-phrases. Fonzi's "hey" was humorous once or twice -- by episode 50 the writers were not earning their salaries. But at least Happy Days had 1 good season.