I'd say concentrate on Sunday before looking towards Santa Clara.
On paper and via the eyeball test, the Patriots should beat Denver. Denver's offense has some glaring issues and Manning actually seems to be a step back from Osweiler at this point. Also, Denver's defense let Pittsburgh move the ball quite a bit in the Divisional Playoff. It certainly seemed like a game that Pittsburgh had in control but let get away from them (much like the Pats in the first NE/DEN meeting this season). DEN is one of those pesky teams that if you let them linger, they seem to find a way to win.
All that being said, Patriots have historically struggled in Denver and quirky things seem to happen to them almost every time they play up there. They are still facing the #1 ranked defense in the NFL and a team that can run the ball pretty well. If the Pats don't bring their A game, this game can certainly be a struggle and could turn into another game that they let slip through their fingers. However, if the Pats bring their A game and are firing on all cylinders, I don't see anyway that DEN can keep pace.