Best strategy against Dwight is usually to play him one-on-one and let him score.
His defense and rebounding drop off in a big way when Dwight has big scoring nights.
Plus, his Houston Rockets teammates are very limited offensively outside of James Harden. If you can do a good job on Harden and lock down their limited supporting cast, you have a good chance at beating this team. Even with Dwight scoring 30-35 points.