I think this starting 5 is very good:
Dwight
Gasol
Artest
Kobe
Nash
I don't think Artest is the defensive presence he used to be, but he's still low utilization. I'd expect Gasol to get the "harder" defensive job, so Dwight can help. Nash is very weak defender, and I'm not sure Kobe and Artest have enough athleticism to make up for it.
I do like the JO backup plan, IFF he stays healthy, which he won't.
Blake is a solid combo guard.
They could really use a guy that can shoot and play D at SG (Delonte without injury problems.) Then they could run out:
Dwight / JO
Gasol / McRoberts
Kobe / Artest
SG
Nash / Blake
with Blake and Kobe backing up the SG. I think that a good coach (do they have that?) makes that rotation work really well.