Since 08, Blazers, but since 2005, maybe Rockets?
Yao+McGrady should've been the best 1-2 punch in the league. Both players just absolutely decimated by injury.
Few years removed, they have Kevin Martin (their top scorer) missing extending time down the stretch, Kyle Lowry (their best player) missing nearly the entire rest of the season with a severe and completely unforeseeable bacterial infection, and this all happens as they're overacheiving to get to the playoffs for the first time since Yao Ming averaged 21 points and 10 boards a game for an entire season.