Although, here is something to consider:
Considering just how thoroughly dominant our starting unit is, it may be worth it to throw an overmatched second unit out there so that the starters can rest at the same time and continue their complete domination as a unit.
In other words, if resting our starters and getting outscored by 10 points over the course of 15 minutes results in our starters able to come in together and outscore opponents by 40 over the course of their 35 minutes, that may be worth it.