As far as I am concerned, this is the question Doc and Thibodeau need to be asking themselves. Do they let Kobe "get his", and try to shut down the rest of the team, or do they try to take the ball out of his hand.
I have a feeling a lot of people have a strong feeling about this (Dennis and Callahan were killing me this morning, claiming it was a no brainer that you throw the whole team at Kobe), but I personally don't think it is so cut and dry.
Personally, I don't think you can do either exclusively. I think the key to this series defensively will not be how we defend Kobe, it will be how he thinks we are defending him. We need to pull something out of Belichick's playbook, and instead of just trying to smother the Lakers, and take one weapon away (I like to oversimplify it as saying they have two weapons, Kobe, and everyone else), they need to try to confuse Kobe, and keep them guessing.
They need to constantly thrown different looks at them. Once Kobe feels comfortable, he can absolutely pick a defense apart, whether it is by finding the open man if everyone is concentrating on him, or by breaking down the defense himself, and singlehandedly scoring.
But if he doesn't know what to expect from play to play, let alone game to game, then it will make it much more difficult for him.
One thing I have noticed with Kobe is that he is a great scorer, and a great playmaker...but he is not great at doing both at the same time. He is not Chris Paul who can switch gears in a fraction of a second. He needs time to switch gears. Generally you will see him pass for a half, or a whole game, and then take the game over for the second half, or the next game. He rarely changes from play to play.
This series is going to be won in the schemes. Tom Thibodeau's incredible attention to detail is going to really come into play. He needs to generate multiple gameplans, and he needs to be able to switch them at the drop of a hat. The only way to slow this team down is if they don't know where the trap is coming from, or if it is coming at all.
We need Kobe to become hessitant, because he doesn't know if Perk is going to blitz him, or if he is going to drop back into the passing lane. We need Kobe to question himself, and not know if he is being given the lane because there is a second and third level waiting to pick him up, or if they are just waiting to jump his pass.
Kobe may beat us when it is all said and done...but the C's need to make him work for it mentally.