He can, but I feel it makes more sense to start Pritchard at PG, White at SG, and Simons plating combo guard off the bench.
Pritchard is an excellent ball handler with a low turnover rate, and high ast:TO ratio and high BBIQ - I feel he is the best equipped to run the offense.
I like White at the SG spot because he's a bigger guard who can switch on multiple positions, and while he's more of a scorer then a playmaker.
I like those two guys starting together because they have both been around the team for a few years now - they know the offence, they know how to play with JB (and with each other) and there will be minimal adjustment. They are also more steady, consistent players.
I like Simons off the bench as a 6th man because I feel like that role just fits his game. He's a less efficient, streaky, volume scorer - exactly the type of guy you can bring off the bench as an offensive spark / wildcard, and he can play both positions so he can cover for both Pritchard and White.