Not in a traditional sense, no. These days it's possible to play like the late 00's Magic teams did, with two quick forwards that spend a lot of time spotting up on the perimeter, only you don't need a dominant rebounder and finisher inside to make it work.
I do think that eventually we're going to see more teams taking advantage of the current undervaluing of traditional big men. Somebody will just put together a full big man rotation of guys who simply can't be contained by your typical combo forward.
Right now, it seems like if you wanted to go after traditional 4/5 types like Faried, Greg Monroe, Tristan Thompson, Ed Davis, Mason Plumlee, Carl Landry, Brandon Bass, etc. .... you can pretty much have your pick without giving up a ton relative to the production you're getting.