Definitely not for everybody as it takes a cynnical and sardonic look at religion and could be offensive to some.
Since I respect, though do not ascribe to, any formal religion, I found it intellectually appealing as it certainly was an evenly dispersed look at what Bill Maher believes to be the absurdity of all organized religions. In other words, no major religions were spared in a forum that at times felt 'Borat-like' during interviews with folks espousing their religious views.
I learned some interesting things about the beliefs displayed in the dogma and foundations of certain religions, but I took it all with a grain of salt as I know too many fine, level-headed people who accept the good that their religion provides for them without getting caught up in the fine print.
Aetheists and agnostics are likely to enjoy it, while serious religious folk may feel that Maher goes too far.