Yes Wilt might still have scored 50ppg because the rules are different now.(that is the problem, you are never sure because he had such incredible athletic talent). His turnaround fall away bank shot was the most unstoppable shot in basketball. When he started in the league he passed for crap. At the end he was an extremely good passer. For him to hit 50ppg, he would need to be able to pass like he did later in life to prevent "hack a Wilt".
I would like to see if the modern players really understand what "and one" means. I once saw a guard grab Wilts arm with both hands and Wilt still dunked the ball with the guy hanging on with both hands. I saw it and still can't believe he did that. The 3pt shot would have helped Wilt tremendously because they wouldn't have doubled teamed him constantly. (people don't remember that Attles was 8 for 8 the night that Wilt scored 100. He didn't take more shots because they wanted Wilt to get 100). If you have a Ray Allen in the corner and Pierce in the other corner, Wilt wouldn't have been double teams all the time. By the way, the Celtics were one of the few teams that didn't double Wilt throughout the game. Wilt would get 35 and 20 but Russell's Celtics would win the game.
In his best day Shaq was never as athletic as Wilt although Shaq might have been as strong in his prime. What was amazing about Wilt and Bill Russell was their tremendous athletic ability even with their size. Wilt was a great shot blocker with a great leap. Russell was out of this world as he actually would stop the ball when he blocked it and then catch it as it went down.
As to his shooting percentages, in much of his early career he was on crap teams and was the first, second and third scoring options. He took a lot of shots that were less than optimum because it was his job.
In reality, it would be best if he only scored 35 but had 10 assists in the modern game.