I think the Sixers are like the Bucks (star player is impossible to contain on drives, but can't shoot outside) with a few differences:
1) Sixers have some shooters, Bucks only have Middleton
2) Simmons is a better distributor than Giannis, combine that with the shooters and they are more trouble on offense
3) They have a fantastic Center
4) But, they don't have the defensive length that the Bucks have, so probably won't force as many fast breaks as the Bucks.
So, yes, I think (<nojinx>in the unlikely event we get there
</nojinx>) we'd see Horford on Simmons and Baynes on Embiid. The rest will have to stay home and smother Redick, Covington and Saric.
C's should probably have more offensive cohesion, better ball movement vs. the Sixers due to less length.