Both Cleveland and Orlando offer unique challenges, but also they each have glaring weaknesses that the C's can exploit for sure. It won't be easy but the C's should still be able to handle either team even without KP.
I personally lean towards wanting Orlando more, because they are still a young and inexperienced team. So far they are 0-3 on the road as well. They remind me a bit of those "bridgey" Celtics in the 2015-2018 range who would typically do great at home but struggle on the road partly because they were young/inexperienced compared to the others.
Orlando could steal a game at TD Garden but it's also likely they lose all of them, and the C's should easily be able to steal 1 or 2 at Orlando. Orlando doesn't have too many true scoring threats either, I think the C's could have a few games where they shoot poorly and still win by double digits just like the Heat series.